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KMID : 0361620120470030171
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Journal of the Korean Orthopaedic Association
2012 Volume.47 No. 3 p.171 ~ p.177
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The Effectiveness of C-Reactive Protein Surveillance as a Method to Monitor the Post-Operative Antibiotics Administration after Total Knee Replacement Arthroplasty
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Bong Hyun-Jong
Moon Jun-Ki
Lee Jin-Kyu
Choi Choong-Hyeok
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Abstract
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Purpose: To evaluate the effectiveness of using C-reactive protein (CRP) surveillance as a method to monitor the effect of postoperative antibiotics for the prevention of early infection after total knee replacement arthroplasty (TKRA).
Materials and Methods: A prospective study was performed in 115 primary TKRAs. We examined the values of CRP of all cases on the 3rd, 5th, 7th, 10th and 14th days post-operatively. Some patients were administrated additional antibiotics under certain specific situations based on the pattern of CRP. The patients were divided into two groups: group I with planned period of administration and group II with administration longer than the planned period.
Results: No acute infection after TKRA due to CRP surveillance was observed. The mean duration of antibiotics administration was 5.9 days in all cases, 5 days in group I and 13.3 days in group II. Twelve cases (10.4%) were included in group II. The CRP was increased on the 5th and 10th days after operation in group II.
Conclusion: The surveillance of CRP was thought to be helpful in monitoring the effects of post-operative antibiotics and prevention of early infection after TKRA.
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KEYWORD
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knee, antibiotic prophylaxis, C-reactive protein (CRP), total knee replacement arthroplasty
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